Postdoc position in cell-migration and systems-scale drug discovery

Postdoc position in cell-migration and systems-scale drug discovery

A shared postdoc position is available between Symphogen A/S and the laboratory of Prof Dr Rune Linding, a world-leading network biologist whose research focuses on the mechanisms by which cells use signaling networks to respond and adapt to changes in their environment. We are seeking a highly motivated and brilliant postdoc to join our highly dynamic, productive and stimulating lab.

The group and our research
The Linding Laboratory is a network biology research group based at the Biotech Research and Innovation Centre at the University of Copenhagen (BRIC). Our lab explores biological systems by both generating high-throughput data and developing algorithms aimed at predicting cell behavior with accuracy similar to those of weather or aircraft models. A major focus of our lab is studying cellular signal processing and decision-making during cancer progression.

Symphogen A/S (www.symphogen.com) is a privately held biotech company based in Ballerup, immediately outside the center of Copenhagen, Denmark. The Company currently employs 90 people. Symphogen’s proprietary technology offers a method for the production of unlimited amounts of highly purified, antigen-specific, recombinant antibody mixtures - a new class of therapeutic anti-bodies with a number of prominent advantages compared to existing monoclonal antibody or immunoglobulin therapies. This new antibody technology has a significant market potential and the company has developed a broad pipeline with two products in clinical development and several preclinical programs.

Project/The research project(s)
In this position, the successful applicant will perform large-scale integrative studies, combining next generation sequencing, global phospho-proteomics and high content screening, with computational models in order to identify the signaling networks involved in cell migration. Following target identification the applicant will generate novel antibody based anti-cancer therapies that can be taken further into pre-clinical and clinical testing.

The identified targets and therapies will be utilized in a network medicine project focused on developing novel treatments for cancer and will be related to our recent studies on phosphorylation networks and network medicine (Creixell et al. 2012 Nature Biotechnology, Erler & Linding Cell 2012, Bakal, Linding et al. Science 2008, Tan et al. Science 2009 and Tan et al. Science 2011 and Jørgensen et al. Science 2009). The project is a collaboration between the Linding Laboratory, Prof. Doug Lauffenburger’s lab at MIT, Prof. Norbert Perrimon’s lab at Harvard, Assoc. Prof. Janine Erler’s lab at BRIC, Symphogen A/S, Silicon Graphics Inc. and PerkinElmer GmbH.

Start: As soon as possible.
Duration: 3 years

Candidates should hold a PhD degree or equivalent in systems biology, molecular biology or other relevant field. Experience in large-scale systems studies, mammalian tissue culture, cell imaging and/or antibody development is desired. Experience in mass-spectrometry and (phospho) proteomics techniques is a distinct advantage.

The post-holder must be keen to generate, analyze and computationally handle large-scale quantitative data to reach a deeper understanding of the biological question at hand. Applicants should be able to work independently and to plan and carry out complicated tasks, while also being part of a large and dynamic group. Strong communication skills in English, both written and spoken are required.

Place of employment
The successful applicant would be employed at BRIC, University of Copenhagen. However the laboratory is physically based on the Technical University of Denmark’s campus in Lyngby. Time will be shared between the Linding Laboratory and Symphogen A/S as required by the project.

Please read more about Linding Laboratory on www.lindinglab.org

For further information regarding the position, please contact Professor Linding at +45 2365 1941 or linding@lindinglab.org.

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 31.951 DKK/ca. 4.250 Euro plus pension. Depending on qualifications, a higher salary may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the "Memorandum on Job Structure for Academic Staff at the Universities" of June 28, 2013.

Application
Your application for must be submitted electronically by clicking ’APPLY NOW’ below or via the university’s job portal on http://employment.ku.dk/faculty/. The application must include the following documents/attachments, which must all be in PDF format:

1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.

Letters of recommendation

Furthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letters must be signed by the supporting persons on paper with institutional letter head and in PDF-format. These should be received before the deadline on jobs@bric.ku.dk with the subject "name candidate-MorphoMap-postdoc-Aug2014"; preferably by the supporting persons. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.

Application deadline: 5th October 2014.

We reserve the right not to consider applications or supplementary material received after deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.

Applications will be assessed according to the Ministry Order on the Appointment of Academic Staff at Universities 2012 and the University of Copenhagen’s guidelines 2013. In addition to the required qualifications, the main criteria for selection will be a strong research potential, personal drive and experience with the above mentioned techniques, methods and area of research.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

’APPLY NOW’
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